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The primary purpose of economic development is creating the well being life for all the people through a good economic developing process year by year. In order to measure the economic development level of a region in some periods, Statistics Manokwari Regency (BPS) uses Gross Domestic Regional Product (GDRP). GDRP is the total of value added produced by all production units in a region or the total of goods and services’ value produced by all production units. The method of generating GDRP devided into three methods, there are by production approach, by expenditure approach, and by income approach. These methods would generate the identical number of GDRP. This book would analyze GDRP by expenditure approach in Manokwari during 2010-2014. By expenditure approach, the biggest expenditure in Manokwari during 2010-2012 was expended to fullfill the household consumption, wheter the food consumption and non-food consumption which spended 72-58 percents of total GDRP. But since 2012, the biggest expenditure in Manokwari shuffled into Gross Fixed Capital Formation which spended around 58-54 percents and exceed the expenditure of household consumption. Generally the total GDRP of Manokwari during 2010-2014 was increasing year after year.